About the Children’s Oncology Group

The Children’s Oncology Group (COG) is the world’s largest organization devoted exclusively to childhood and adolescent cancer research. The COG unites more than 9,000 experts in childhood cancer at more than 220 leading children’s hospitals, universities, and cancer centers across North America, Australia, New Zealand, and Europe in the fight against childhood cancer. Today, more than 90% of the 14,000 children and adolescents diagnosed with cancer each year in the United States are cared for at COG member institutions. The COG research has turned childhood cancer from a virtually incurable disease 50 years ago to one with a combined 5-year survival rate of 80% today. COG's goal is to cure all children and adolescents with cancer, reduce the short and long-term complications of cancer treatments, and determine the causes to find ways to prevent childhood cancer.

There are approximately 14,000 new cases of childhood cancer each year in the United States. The most common cancer, acute lymphoblastic leukemia, occurs in approximately 3,500 children each year in the US. The incidence of many childhood cancers, however, is less than 1,000 cases/year, and a number occur in less than 100 children/year. Yet, for a family with a child diagnosed with cancer, it makes no difference whether the cancer is common or rare – their child deserves the best chance at a cure.

Pediatric MATCH

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice), also known as Pediatric MATCH, is a pediatric precision medicine cancer treatment trial that explores whether targeted therapies can be effective for children and adolescents with solid tumors that harbor specific gene mutations. Pediatric MATCH is a phase 2 trial that will investigate more than eight different study drugs, each targeting a defined set of gene mutations, in order to match patients with therapies aimed at the molecular abnormalities in his or her tumor.

Click here to learn more about the COG's Pediatric MATCH.

G9 is the first private foundation to provide financial support to Pediatric MATCH.

Project: EveryChild

Project: EveryChild will be centered on a single research study that will capture the biology and outcome of very child with cancer cared for in a COG program (more than 220 programs internationally). Participation will  be offered to every child diagnosed with cancer, no matter how common or rarethe cancer may be. Key clinical data on disease presentation,  theraputic  approach and outcome will leverage the COG infrastructure. Althoughmany children will also be offered the opportunity to enroll in a COG theraputic study, such enrollment will not be a requirement. Biospecimens, including tumor tissue will be stored at COG's state-of-the-art biorepository located at The Research Institute of Nationwide Children's Hospital (the largest pediatric cancer biospecimen bank in the nation).

Click here to learn more about COG's Project:EveryChild.